【報告題目】Ultra-Sensitive Raman Nanoparticles for Detection of Microscopic Cancer

【報告人】黃銳敏博士

【邀請人】黃秋博士

【時間】12月9日（周三）16：00-17：00

【地點】Med-X 108 （閔行文選樓323會議室同步視頻）

【摘要】The inability to visualize the true extent of cancers represents a significant challenge in many areas of oncology. Furthermore, the multifocal microscopic satellite lesions represent a major reason for tumor local recurrences and metastatic spread. An imaging method to reveal the tumor extent is desired clinically and surgically. To this end, a novel surface-enhanced resonance Raman scattering (SERRS) nanoparticles (SERRS-nanostars), which feature a star-shaped gold core, a Raman reporter resonant in the near-infrared spectrum, and a primer-free silication method, has been developed.

SERRS-nanostars enabled the visualization of the full tumor extent in state-of-the-art mouse models of breast cancer, sarcoma, pancreas cancer and prostate cancer, without requiring a dedicated targeting moiety; in other words, a “one-probe-fits-all” concept. The precise visualization of tumor margins, microscopic tumor invasion, multifocal loco-regional tumor spread, and even premalignant lesions using SERRS-nanostars Raman imaging was demonstrated. High sensitivity (1.5 femtomolar limit of detection) and broad applicability, in conjunction with their inert gold-silica composition, render SERRS-nanostars a promising imaging agent for more precise cancer imaging and resection.

【報告人簡介】黃銳敏博士於1999年在中國科學技術大學分子生物學與細胞生物學系獲得學士學位👳🏼，於2004年在中國科意昂4上海生命科學意昂4生物化學與細胞生物學研究所獲得博士學位🤦🏿‍♂️，同年赴美國斯隆凱特琳癌症研究中心從事博士後研究，現任該中心放射醫學系的Senior Research Scientist🔷。

黃博士師從分子影像學的先驅Ronald Blasberg和Moritz Kircher博士👨🏼‍🎨，她的主要研究方向是將分子影像學在腫瘤生物學中的轉化應用。她當前的研究主要集中在應用光學分子成像技術（含拉曼光譜成像，熒光成像和生物發光成像）及放射性同位素成像技術（含正電子發射計算機斷層顯像(PET)和單光子發射計算機斷層掃描成像(SPECT)），在小鼠腫瘤模型中在體無損地檢測：1）浸潤性腫瘤邊界；2）腫瘤微轉移竈👨🏽‍🌾；3）前哨淋巴結的腫瘤轉移；4）腫瘤對藥物處理的反應🤚；5）腫瘤微環境細胞通訊🍙。