To extend the limit of current imaging techniques, a series of multifunctional nanomaterials, including highly sensitive imaging probes and ultra-low toxicity contrast agent have been developed and applied to a variety of practical clinical scenarios including intraoperative imaging of tumor margins and delineation of lymphatic system. Among them, the ultrasensitive Gap-enhanced Raman tags (GERTs) probes are undergoing clinical translation and potential commercial exploitation. 

Highly sensitive probes based on multifunctional polymer dots for lymphatic system imaging

Selected Publications🪂：

1. Lin L, Zapata M, Xiong M, et al. Nanooptics of plasmonic nanomatryoshkas: shrinking the size of a core–shell junction to subnanometer. Nano Letters, 2015, 15: 6419-6428.

2. Zhang Y, Gu Y, He J, Thackray B, and Ye J, Ultrabright gap-enhanced Raman tags for high-speed bioimaging. Nature Communications, 2019, 10: 3905.

3. Bao Z, Zhang Y, Tan Z, et al. Gap-enhanced Raman tags for high-contrast sentinel lymph node imaging. Biomaterials, 2018, 163: 105-115.

4. Zhang Y, Liu Z, Thackray B, et al. Intraoperative Raman-guided chemo-photothermal synergistic therapy of advanced disseminated ovarian cancers. Small, 2018, 14: 1801022.

5. Cao F, Guo Y, Li Y, et al. Fast and accurate imaging of lymph node metastasis with multifunctional near-infrared polymer dots. Advanced Functional Materials, 2018, 28: 170717.