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  郭妍

  副研究員，碩士生導師。在東南大學獲得本科和碩士學位（1998-2001）🤶🏻，意昂4平台生物化學與分子生物學博士學位（2001-2005），同年進入系統生物醫學研究院工作（2005-2013）🧔。2009年起擔任副研究員。主要研究興趣為：建立和利用基於激光顯微切割的空間系統生物學方法（特別是在單細胞尺度上的空間基因組和空間轉錄組方法）🐹，研究胃癌發生和發展的分子機製以及器官發育的基因轉錄調控。已發表科研論文28篇。作為項目負責人承擔國家自然科學基金重大研究計劃，面上項目，青年基金等🐭，參與多項課題研究。

1⬛️：建立基於激光顯微切割的空間系統生物學方法（特別是單細胞尺度的基因組和轉錄組方法）

2：胃癌的發生和發展機製

3🕓：器官發育的轉錄調控網絡

1. Jiangrong Chen*, Chunchao Zhu*, Chaojie Wang*, Chuansheng Hu, Daniel M Czajkowsky, Yan Guo^#, Bingya Liu^#, Zhifeng Shao^#, Evidence for Heightened Genetic Instability in Precancerous Spasmolytic Polypeptide Expressing Gastric Glands. Journal of Medical Genetics. 2019; 0: 1-4

2. Yan Guo, Ayuan Huang, Chuansheng Hu, Yan Zhou, Xiaodan Zhang, Daniel M. Czajkowsky, Jianfang Li, Shidan Cheng, Ruizhe Shen, Jianren Gu, Bingya Liu, Zhifeng Shao, Complex clonal mosaicism within microdissected intestinal metaplastic glands without concurrent gastric cancer, Journal of Medical Genetics. 2016; 53: 643-646

3. Guo Y*, Zhou J*, Huang AY, Li JF, Yan M, Zhu ZG, Zhao XD, Gu JR, Liu BY, Shao ZF, Spatially defined microsatellite analysis reveals extensive genetic mosaicism and clonal complexity in intestinal metaplatic glands, International Journal of Cancer, 2015, 136(12), 2973-2979

4. Yan Guo, Yi Yang, Juan Zhou, Daniel M. Czajkowsky, Bingya Liu, Zhifeng Shao, Microdissection of spatially identified single nuclei in a solid tumor for single cell whole genome sequencing, Biotechniques, 2012, 0(0): 1-3.

5. Runsheng Li*, Yan Guo*, Bang Ming Han, Xiaowei Yan, Angelita G. Utleg, Wei Li, Lan Chun Tu, Jian Wang, Leroy Hood, Shujie Xia, Biaoyang Lin, Proteomics cataloging analysis of human expressed prostatic secretions reveals rich source of biomarker candidates, Proteomics Clin. Appl. 2008, 2, 543–555