• 李瑤

    李 瑤🤞🏼,博士,意昂4体育平台,教授🏄🏼‍♂️,博士生導師, 院長助理🕤。李瑤博士於2002年獲得意昂4平台電子與信息工程本科學位,2008年在美國紐約州立大學石溪分校獲得電子與計算機工程博士學位,2008年至2010年於美國石溪醫學研究中心任高級研究員。2010年加入意昂4体育平台。先後獲得國家自然科學基金委員會、科技部、教育部🌋⭐️、上海市科委和意昂4平台的多項基金支持🔗,並在國外重要學術期刊如《Science》,《Brain》,《Magnetic Resonance in Medicine》等發表100余篇學術論文,他引超千次。研究工作獲得2021年國際醫學與生物學工程學會年會(EMBC)最佳論文獎(Best Paper Award, First place)🪔;在2019-2021年國際磁共振學術年會(ISMRM)上連續獲得13項大會優秀論文獎🦈;獲得2018年上海市醫學會精神醫學專科學術年會優秀論文一等獎,2019 、2020年中華醫學會第十七🫳🏿、十八次全國精神醫學大會優秀論文獎。獲得國家自然科學基金👨‍👨‍👧‍👧、科技部🥊、教育部🔌、上海市科委和意昂4平台的多項基金支持,授權發明專利多項。現任BMC Neuroscience雜誌副主編🧑🏿‍💻,美國電氣和電子工程師協會高級會員(Senior Member),提名IEEE EMBS國際生物醫學工程學會行政委員會委員(2020),國際醫學磁共振學會(ISMRM)會員🦴,人類腦成像組織(OHBM)會員, IEEE EMBC Shanghai分會秘書😐🙅🏿‍♀️。獲得意昂4平台“晨星學者”獎勵計劃🚣🏽‍♂️,瑞金醫院“廣慈學者”雙聘教授等。

研究方向
高分辨率磁共振波譜成像👵🏿、深度學習及多模態磁共振腦影像、新型腦成像技術在神經/精神系統疾病中的轉化研究
科研項目
1. 上海市科委“基礎研究特區計劃”項目🙂,  無創解密人腦分子代謝指紋, 2021年11月-2026年10月,1000萬🕺🏿,課題負責人
2. 國家自然基金面上項目,基於全腦高分辨率磁共振波譜成像技術的強迫症患者神經代謝異常研究🧚‍♂️,2019/1-2022/12🎸,56萬,課題負責人
3. 意昂4平台“醫工交叉基金”重點項目🔤,強迫症決策信心神經網絡的功能與代謝耦合研究💁,2021/1-2023/12,100萬🏌🏼🪒,課題負責人
4. 意昂4平台“重點前瞻布局基金”, 高分辨率人腦結構、功能、代謝快速一體化成像技術研究🫷🏼,2020/01-2021/12,100萬,課題負責人
5. 上海張江國家自主創新示範區專項發展資金重大項目👱🏿,"中國人腦分子與功能圖譜" 項目,2019/11-2020/12🧝🏿‍♂️🤒,95萬,課題負責人


代表性論文專著

1. Zhang M, Guan Z, Zhang Y, Sun W, Li W, Hu J, Li B, Ye G, Meng H, Huang X, Lin X, Wang J, Liu J, Li B, Li Y*, Disrupted coupling between salience network segregation and glucose metabolism is associated with cognitive decline in Alzheimer's disease - A simultaneous resting-state FDG-PET/fMRI study, NeuroImage: Clinical, 34: 102977, 2022.

2. Li W, Xu J, Xiang Q, Zhuo K, Zhang Y, Liu D, Li Y*, Neurometabolic and functional changes of default-mode network relate to clinical recovery in first-episode psychosis patients: A longitudinal 1H-MRS and fMRI study, NeuroImage: Clinical, 34: 102970, 2022.

3. Wang T, Hu Y, Wang D, Liu J, Sun J, Wei C, Dai H, Li Y*, Arcuate fasciculus subsegment impairments distinctly associated with memory and language deficits in acute mild traumatic brain injury patients, Journal of Neurotrauma, 38(23): 3279-87, 2021. 

4. Lu J, Mei Q, Hou X, Manaenko A, Zhou L, Liebeskind D, Zhang J, Li Y*, Hu Q, Imaging acute stroke: from one size fits all to biomarkers, Frontiers in Neurology, 12: 697779, 2021.

5. Ye Q, Zhang Z, Sun W, Fan Q, Li Y*, Disrupted functional connectivity of precuneus subregions in obsessive-compulsive disorder, NeuroImage: Clinical 31: 102720, 2021

6. Li Y, Xiong J, Guo R, Zhao Y, Li Y, Liang Z, Improved estimation of myelin water fractions with learned parameter distributions, Magnetic Resonance in Medicine, 86(5): 2795-2809, 2021.

7. Wang D, Zhuo K, Sun Y, Xiang Q, Guo X, Wang J, Xu Y, Liu D*, Li Y*, Middle temporal corpus callosumimpairment as a predictor of eight-week treatment outcome of drug-naïve first-episode psychosis patients: A pilot longitudinal study, Schizophrenia Research 232: 95-97, 2021.

8. Zheng Y, Wang D, Ye Q, Zou F, Li Y*, Kwok S, Diffusion property and functional connectivity of superior longitudinal fasciculus underpin human metacognition, Neuropsychologia 156(107847), 2021.

9. Meng Z, Guo R, Li Y, Guan Y, Wang T, Zhao Y, Sutton B, Li Y and Liang Z-P, Accelerating T2 mapping of the brain by integrating deep learning priors with low‐rank and sparse modeling, Magnetic Resonance in Medicine, 85(3):1455-1467, 2021.

10. Guo R, Zhao Y, Li Y, Wang T, Li Y, Brad S, and Liang ZP, Simultaneous QSM and metabolic imaging of the brain using SPICE: Further improvements in data acquisition and processing, Magnetic Resonance in Medicine, 85(2):970-977, 2021.

11. Li Y*, Wang T, Zhang T, Lin Z, Li Y, Guo R, Zhao Y, Meng Z, Liu J, Yu X, Liang Z-P and Nachev P, Fast high-resolution metabolic imaging of acute stroke with 3D magnetic resonance spectroscopy, Brain (封面論文), 143(11): 3225–3233, 2020.

12. Bo B, Li Y*, Li W, Wang Y, and Tong S, Optogenetic translocation of protons out of penumbral neurons is protective in a rodent model of focal cerebral ischemia, Brain Stimulation, 13: 881-890, 2020.

13. Cen H, Xu J Xu, Yang Z, Mei L, Chen T, Zhuo K, Xiang Q, Song Z, Wang Y, Guo X, Wang J, Jiang K, Xu Y, Li Y*, and Liu D, Neurochemical and brain functional changes in the ventromedial prefrontal cortex of first-episode psychosis patients: A combined functional magnetic resonance imaging - proton magnetic resonance spectroscopy study, Australian & New Zealand Journal of Psychiatry, 54(5):519-527, 2020.

14. Guo R, Zhao Y, Li Y, Li Y, and Liang ZP, Simultaneous metabolic and functional imaging of the brain using SPICE, Magnetic Resonance in Medicine, 82(6):1993-2002, 2019.

15. Zhuang H, Liu R, Wu C, Meng Z, Wang D, Liu D, Liu M, and Li Y*, Multimodal classification of drug-naïve first-episode schizophrenia combining anatomical, diffusion and resting state functional resonance imaging, Neuroscience Letters, 705:87-93, 2019.

16. Xiang Q, Xu J, Wang Y, Chen T, Wang J, Zhuo K, Guo X, Zeljic K, Li W, Sun Y, Wang Z, Li Y*, and Liu D, Modular functional-metabolic coupling alterations of frontoparietal network in schizophrenia patients, Frontiers in Neuroscience, 13:40, 2019. 

17. Bo BLi Y*, Li WWang Y, and Tong S, Optogenetic excitation of ipsilesional sensorimotor neurons is protective in acute ischemic stroke: a laser speckle imaging study, IEEE Transactions on Biomedical Engineering, 66(5):1372-1379, 2019.

18. Chen Y, Meng Z, Zhang Z, Zhu Y, Gao R, Cao X, Tan L, Wang Z, Zhang H, Li Y*, Fan Q, and Xiao Z, The thalamic glutamate level correlates with functional connectivity with dorsal anterior cingulate cortex/middle occipital gyrus in obsessive-compulsive disorder: a combined fMRI and 1H-MRS study, Australian & New Zealand Journal of Psychiatry, 53(3): 207-218, 2019.

19. Tang Y, Zhang X, Sheng J, Zhang J, Zhu Y, Wang J, Zhang T, Zhuo K, Zhang X, Tong S, Li Y*, and Wang J, Elevated hippocampal choline level is associated with altered functional connectivity in females with major depressive disorder: A pilot study, Psychiatry Research: Neuroimaging, 278: p. 48-55, 2018.

20. Wang R, Fan Q, Zhang Z, Chen Y, Zhu Y and Li Y*, Anterior thalamic radiation structural and metabolic changes in obsessive-compulsive disorder: a combined DTI-MRS study, Psychiatry Research: Neuroimaging, 277:39-44, 2018. 

21. Li Y, Chen Z, Su X, Zhang X, Wang P, Zhu Y, Xu Q, Xu J and Tong S, Functional lateralization in cingulate cortex predicts motor recovery after basal ganglia stroke, Neuroscience Letters, 613(2): 6-12, 2016.

22. Zhang X, Tang Y, Maletic-Savatice M, Sheng J, Zhang X, Zhu Y, Zhang T, Tong S, Wang J and Li Y*, Altered neuronal spontaneous activity correlates with glutamate concentration in medial prefrontal cortex of major depressed females: an fMRI-MRS study, Journal of Affective Disorders, 201:153-161, 2016.

23. Zhu Y, Fan Q, Han X, Zhang H, Chen J, Wang Z, Zhang Z, Tan L, Xiao Z, Tong S, Maletic-Savatic M and Li Y*, Decreased thalamic glutamate level in unmedicated adult obsessive compulsive disorder patients detected by proton magnetic resonance spectroscopy, Journal of Affective Disorders, 178:193-200, 2015. 

24. Li Y*, Zhu S, Yuan L, Lu H, Li H and Tong S, Predicting the ischemic infarct volume at the first minute after occlusion in rodent stroke model by laser speckle imaging of cerebral blood flow, Journal of Biomedical Optics, 18 (7): 076024, 2013. 


聯系方式

郵箱地址:yaoli@sjtu.edu.cn

聯系電話🧝🏻‍♀️:86-21-62932981

辦公地址🌊:教三樓南樓331室

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